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■ Application of Highly Active TEMPO Derivatives for Electrochemical Analysis

Fumiya Sato, Masayuki Kumano, Haruka Nakano, Kyoko Sugiyama, Tsutomu Fujimura, Katsuhiko Sato,* and Kazuhiro Watanabe*

*Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba, Sendai, Miyagi 981-8558, Japan

Abstract

The electrochemical properties of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) derivatives with improved oxidative capability upon introducing electron-withdrawing groups were evaluated by cyclic voltammetry. Synthesized TEMPO derivatives, including 4-acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (A-TEMPO), 4-trifluoroacetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (F-TEMPO), and dinitroxide condensed with TEPMO exhibiting a 1,2-dicarbonyl structure, 4,4′-[(1,2-dioxo-1,2-ethanediyl)diimino]bis[2,2,6,6-tetramethyl-1-piperidinyloxy] (di-TEMPO), were used as electrocatalysts. Ethanol and vancomycin response currents were compared, demonstrating the potential of specific TEMPO derivatives for quantification. TEMPO derivatives showed enhanced response current increase, suggesting their molecular recognition ability.