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Paper | Regular issue | Vol 106, No. 6, 2023, pp.977-992
Published online, 9th May, 2023
DOI: 10.3987/COM-23-14853
Synthesis and Biological Assessment of Novel Heterocyclic Nucleoside Analogues Using Microwave-Assisted Hantzsch Reaction

Abdelaaziz Ouahrouch,* Jamal Krim, and Moha Taourirte

*Laboratory of Biotechnology, Materials and Environment, Faculty of Sciences, Ibn Zohr University, Agadir 80000, Morocco


This paper reports a one-pot synthesis of 5-(1,4-dihydropyridyl) derivatives of 2’-deoxyuridines using Hantzsch condensation of 5-formyl-2’-deoxyuridine and NH4OAc with diverse β-dicarbonyl compounds under solvent-free microwave irradiation conditions. The synthesized compounds were evaluated for their antiviral activities against human rhinovirus (HRV) and hepatitis C virus (HCV), as well as antibacterial activities against a series of Gram-positive and Gram-negative bacteria. The products carrying an unsymmetrical 1,4-dihydropyridyl moiety showed excellent antiviral activity against HCV.