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■ N-Alkylation of Azoles with Enones Assisted by P(III) or Fe2O3-Nanoparticles as Recyclable Catalyst

Elangbam Pinky Devi, Saibabu Polina, Kamal Kant, Arup K. Kabi, Nabil Al-Zaqri, Nayyef Aljaar, and Chandi C. Malakar*

*Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal-795004, Manipur, India

Abstract

Hexamethylphosphorous triamide (HMPT)-assisted and Fe2O3-nanoparticles (NPs) catalysed approaches towards the formation of C-N bond is described by the reaction between azoles and enone-compounds. The transformations were accomplished under mild conditions at temperatures 25 °C and 50 °C respectively. The efficacy and robustness of the reaction conditions can be envisioned by regioselective construction of N-heterocyclic scaffolds embedded with cycloalkyl residue. The established reaction conditions were found competent over a series of enones and azole derivatives to furnish the desired molecules in high yields ranging from 52-86% under P(III)-mediated conditions and 67-86% under the influences of Fe2O3-NPs as recyclable catalyst. It was observed that the catalyst can be recycled up to six times with good yields of the product.