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■ (7S)-Macaureas A and B, Two Urea Analogues from the Roots of Lepidium meyenii

Hui-Chun Geng, Shi-Yu Qiu, Shi-Wei Chen, Song-Mei Lu, Fu-Wen Yang, Ji-Rui Wei, Yong-Hui He,* and Min Zhou*

*Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, China

Abstract

(7S)-Macaureas A and B (1 and 2), two urea derivatives were isolated from the roots of Lepidium meyenii (Maca) collected from Qujing, Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic data, including 1D NMR, 2D NMR and HRESIMS techniques. The absolute configuration of (−)-1 was corrected as 7S by a concise three-step synthesis from commercially available Boc-L-proline. Macaureas A and B were tested for their cytotoxicities against five human cancer cell lines.