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Review | Regular issue | Vol 106, No. 6, 2023, pp.925-967
Published online, 14th April, 2023
DOI: 10.3987/REV-23-1004
Advances on Catalytic Approaches towards the Synthesis of Quinoline Derivatives Using Povarov Reaction

Kamal Kant, Sourav Banerjee, Chandresh K. Patel, Sangita Kalita, Reetu Reetu, Priyadarshini Naik, Nayyef Aljaar, and Chandi C. Malakar*

*Department of Chemistry, National Institute of Technology Manipur, Imphal-795004, India

Abstract

The aza-Diels-Alder reaction is a [4+2] cycloaddition, involving the insertion of nitrogen atom into dienes or dienophiles. A series of biologically and pharmaceutically active essential heterocycles have been developed as a result of this approach. This method witnessed as a powerful tool for the construction of a diverse range of biological active quinoline scaffolds and other nitrogen containing heterocyclic compounds due to its operational modesty, high atom economy, regio- and stereoselectivity. The present report focuses on the advancement of aza-Diels-Alder reaction for the synthesis of optically active and inactive quinoline derivatives.