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Short Paper | Regular issue | Vol 106, No. 3, 2023, pp.500-510
Published online, 15th February, 2023
DOI: 10.3987/COM-23-14807
■ Synthesis and Fungicidal Activities of 5-Aryl-1,3,4-oxadiazolyl 2-Thioether Derivatives Containing Strobilurin Motif

Hongtao Wang, Wenliang Zhang, and Xiaohua Du*

*Catalytic Hydrogenation Research Center, Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

A novel class of 2,5-disubstituted 1,3,4-oxadiazole derivatives was synthesized through active substructure splicing by using kresoxim-methyl as the lead compound. The structure of the title compound was confirmed via structural characterization, and the preliminary assessment of the fungicidal activities revealed that compounds 6b, 6k, 6m, 6n, and 6o are active against Pyricularia oryzae Cav. to a comparable degree to kresoxim-methyl (50 mg/L). Further, control experiments revealed that 6o exhibited in vitro fungicidal activity against P. oryzae Cav., having a median effective concentration (EC50) of 10.03 mg/L, slightly higher than that of kresoxim-methyl (14.21 mg/L). Therefore, 6o is a promising lead compound that warrants further investigation.