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Review | Regular issue | Vol 106, No. 5, 2023, pp.819-839
Published online, 31st March, 2023
DOI: 10.3987/REV-23-1003
Evaluation of 1,3-Thiazole Derivatives with Pharmaceutical and Chemical Activity: a Review

Sheetal Tresa Fernandes, Jyothi Damodara,* and Smitha Maria DSouza

*Department of Chemistry, St Joseph Engineering College, Mangaluru, India. 


1,3-Thiazole is one of the most adaptable scaffolds for heterocyclic compounds. In recent years, thiazole has attracted focus in organic and medicinal chemistry due to its improved effectiveness and significant biological activities. Numerous reviews have reported on the synthesis and pharmacological activities of thiazoles. However, synthesis, pharmaceutical, and chemical applications have not been completely reviewed. The present review focuses on recent work on the synthesis, pharmaceutical and chemical applications of substituted thiazoles. This review discusses the most recent advancements in thiazole-based compounds and emphasizes the importance of design, drug discovery, and the use of thiazole in chemical applications. Additionally, this article is aimed to aid researchers in identifying potential future avenues for the creation of more effective thiazoles.