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Short Paper | Regular issue | Vol 106, No. 3, 2023, pp.488-499
Published online, 26th January, 2023
DOI: 10.3987/COM-22-14799
A New Compound Embeloside A with Hypoglycemic Potential from the Fruits of Embelia oblongifolia Hemsl.

Ying Xu, Yuqi Sun, Bing Liu, Ning Chen, Yingjie Liu, Dongxue Wang, Lei Yu,* and Haifeng Wang*

*School of Pharmacy, Harbin University of Commerce, Harbin, 150076, China


A total of eleven compounds were isolated from the ripe and dried fruits of Embelia oblongifolia Hemsl. Compound 1 was a new one named embeloside A, in addition, compounds 2-4, 6 and 10 were isolated from this genus for the first time. Their molecular structures were elucidated by 1D/2D NMR spectroscopic analysis, HR-ESI-MS spectral data and charged aerosol detector (CAD). Further, hypoglycemic activity evaluation showed that compound 1 could reduce the fasting blood glucose levels in diabetic rats. Therefore, the results suggest that compound 1 might provide a theoretical basis for the development of potential hypoglycemic drugs. The discovery of compounds 1-11 might provide experimental guidance for the further development of Embelia oblongifolia Hemsl.