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Communication | Regular issue | Vol 106, No. 2, 2023, pp.271-276
Published online, 10th January, 2023
DOI: 10.3987/COM-22-14797
On the Reactivity of 2-Methylene-3-quinuclidinone in Water

Rune Ringom, Tim Blizzard, Corine Sandström, Per H. Svensson, and Lars Hagberg*

*Department of Chemistry, Aprea Therapeutics, Hälsovägen 16, Sweden


The biologically active Michael acceptor 2-methylene-3-quinuclidinone (MQ) has a unique chemical reactivity and forms several products upon dissolution in water. With the use of X-ray, NMR and LCMS data the structures of two previously incorrectly characterised compounds are rectified. A complex equilibrium in water, containing novel dimeric species of MQ, and its dependence on temperature, pH and concentration is presented.