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Paper | Regular issue | Vol 106, No. 3, 2023, pp.439-454
Published online, 2nd February, 2023
DOI: 10.3987/COM-22-14801
■ Design, Synthesis, and Biological Evaluation of New Di-arylimidazole-Quinazolinone Hybrid

Parsa Moghimirad, Shahin Boumi, Seyed Nasser Ostad, Maliheh Barazandeh Tehrani,* and Mohsen Amini*

*Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran14176, Iran

Abstract

The aim of this study is synthesis of new diarylimidazole-quinazolinone hybrid derivatives to target two binding sites of tubulin, an attractive target for design of anticancer drugs. In this report, the location of the accessible space of active site was determined by comparing the crystal structure of different inhibitors in tubulin structure. The docking and molecular dynamic simulations were used to confirm the position and stability of designed compounds. Thirteen new compounds were synthesized and their cytotoxicity were studied on three types of cancerous cell lines. Some of the synthesized compounds showed remarkable anti-proliferative activity in cell culture study.