HETEROCYCLES

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■ Silver(I) Complexes Bearing Amine-Functionalized N-Heterocyclic Carbenes: Synthesis, Antimicrobial and Theoretical Studies

Beyhan Yiğit, Hasan Akdan, Muhittin Önderci, Selami Günal, Tuğba Taskin-Tok, Murat Yiğit,* and İsmail Özdemir

*Department of Chemistry, Faculty of Science and Art, Adıyaman University, 02040 Adıyaman, Turkey

Abstract

In this study, a series of amine functionalized benzimidazolium salts and their silver(I) N-heterocyclic carbene complexes were synthesized and characterized by FT-IR, 1H NMR and 13C NMR spectroscopy and mass spectrometry. All the compounds were evaluated for their antibacterial and antifungal activities. They showed antibacterial activity with MIC values in the range of 12.5-50 µg/mL and and antifungal activity with MIC values in the range of 25-100 µg/mL. Notably, compounds 3d and 3e exerted antibacterial activity against all tested gram negative and gram positive bacteria including Staphylococcus aureus MRSA strain with a quite low MIC value of 12.5 µg/mL. Besides these, computational study was applied to understand the biochemical activity analyzes of Ag complexes 3a-e. The findings suggest that there are components 3a and 3b with potential drug properties for future advance researches.