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Review | Regular issue | Vol 106, No. 3, 2023, pp.411-422
Published online, 25th October, 2022
DOI: 10.3987/REV-22-992
Recent Advances in the Synthesis of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole Compounds: A Mini-Review

Jin Luo,* Puqing Chen, and Chonghu Song

*Analytical and Testing Center, Jiangxi Normal University, Nanchang, Jiangxi 330022, China


1,2,4-Triazolo[3,4-b][1,3,4]thiadiazoles are important sulphur- and nitrogen-containing fused heterocycles that can act as promising scaffolds exhibiting outstanding biological activities. Herein, we focused on the major synthetic pathways and methodologies for the synthesis of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole compounds in an attempt to facilitate the discovery of unique 1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole derivatives with improved biological activities.