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Review | Regular issue | Vol 106, No. 2, 2023, pp.241-269
Published online, 6th September, 2022
DOI: 10.3987/REV-22-990
Mini Review on Pyrido[2,3-c]coumarins Backbone of Santiagonamine Antibiotics

Prasanta Patra* and Susanta Patra

*Chemisty, Jhargram Raj College, West Bengal, Jhargram College Rd, Jhargram, West Bengal, India


Santiagonamine is a natural coumarin fused pyridine, specifically pyrido[2,3-c]coumarin derivative having wound-healing activities and is extracted from stems and branches of the South American shrub Berberis darwinii Hook. It was isolated by Shamma et al. in 1984. Both coumarin and pyridine represent an important class of a multi tasking and multi functional scaffolds in organic synthesis. So, the syntheses of coumarin fused pyridine derivatives have an immense impact in the field of organic and pharmaceutical chemistry due to various biological activities displayed by such classes of compounds as well as for their natural occurrences. The main purpose of this review is to focus on different synthetic methodologies for the synthesis of specifically pyrido[2,3-c]coumarins as it is the backbone of santiagonamine antibiotics. Several methods for the synthesis of pyrido[2,3-c]coumarins have been described in the literature, most of which use 3-aminocoumarin as the starting material.