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Review | Regular issue | Vol 104, No. 10, 2022, pp.1709-1743
Published online, 12th July, 2022
DOI: 10.3987/REV-22-983
Total Synthesis of (−)-Exiguolide, a Potent Anticancer Marine Macrolide

Haruhiko Fuwa*

*Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan


(−)-Exiguolide is a marine macrolide natural product, isolated by Ohta and co-workers from a rare marine sponge, Geodia exigua Thiele, collected off Amami-Oshima, Japan. The structural complexity and potent anticancer activity of this natural product spurred the interest of the synthetic chemistry community. This review will focus on total and formal syntheses of exiguolide by Lee, Fuwa, Roulland, Scheidt, Reddy, Song, and Ishihara to illustrate advances in strategies for macrolide synthesis.