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■ Access to Functionalized Pyrrolophenanthridine via an ortho C-H Amination/Interannular C-H Arylation Cascade of N-Arylpyrroles

Jitan Zhang,* Yuhang Li, Pengpeng Sun, Yue Zhang, Meihua Xie,* and Jiaping Wu*

*College of Chemistry and Materials Science, Anhui Normal University, 189 Jiuhua Nan Road, Wuhu, Anhui, 241002, China

Abstract

An expeditious access to pyrrolophenanthridine scaffold enabled by a Catellani strategy from N-arylpyrroles and O-benzoylhydroxylamines is disclosed. This reaction proceeds smoothly involving an ortho C-H amination/interannular C-H arylation cascade and well tolerates a number of pyrrole and amine substrates. Furthermore, the potential of this protocol has been highlighted by the easily accessible scale-up synthesis and a plausible mechanism of this reaction was also proposed.