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Paper | Regular issue | Vol 104, No. 6, 2022, pp.1033-1042
Published online, 11th April, 2022
DOI: 10.3987/COM-22-14633
An Efficient Synthesis of (Aryl)(4-(2-(arylethynyl)-phenyl)-1H-pyrrol-3-yl)methanone from the Reaction of (E)-1-Aryl-3-(2-(arylethynyl)phenyl)prop-2-en-1-one and p-Toluenesulfonylmethyl Isocyanide

Zhongwei Sun, Chengkai Wang, Fang Li, Zifeng Zhang,* and Liangce Rong*

*School of Chemistry and Materials Science, Jiangsu Normal University, No. 101, Shanghai Road, Tongshan New District, Jiangsu, Xuzhou, China


Herein we reported a facile approach to synthesize pyrrole derivatives under mild conditions. The reaction proceeds cycloaddition reactions between (E)-1-aryl-3-(2-(arylethynyl)phenyl)prop-2-en-1-one and commercially available p-toluenesulfonylmethyl isocyanide. Although the triple bond in the substrate was not involved in the reaction process, this work still provided a method for the synthesis of pyrrole derivatives