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Short Paper | Regular issue | Vol 104, No. 6, 2022, pp.1123-1130
Published online, 2nd March, 2022
DOI: 10.3987/COM-22-14626
Concise Semi-Synthesis of a Flavone Glycoside from Marine Angiosperm

Lisha Wu, Shiqiang Yan,* and Limei Huang

*College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, China


Starting from commercially available scutellarin, a natural flavonoid glycoside 6-hydroxyapigenin-7-O-(6”-O-(E)-coumaroyl)-β-glucopyranoside was semi-synthesized in a linear 6-step sequence with an overall yield of 31.5%. This work definitely laid the foundation for the further pharmacological study of this natural compound.