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Paper | Regular issue | Vol 104, No. 5, 2022, pp.925-933
Published online, 8th March, 2022
DOI: 10.3987/COM-22-14628
Inhibition of Amyloid β Aggregation by p-Terphenyl Derivatives Isolated from Boletopsis leucomelas

Akihisa Kobori, Kentaro Hosaka, and Hideyuki Shigemori*

*Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan

Abstract

The number of patients with Alzheimer's disease (AD) is increasing rapidly. Amyloid polypeptides are thought to be involved in the pathogenesis of the disease. Amyloid-β (Aβ), which aggregates in the brain, is cytotoxic and is considered the cause of AD. Therefore, inhibiting the aggregation of amyloid polypeptides and degrading existing amyloid aggregates is a promising approach for the treatment and prevention of the disease. In the present study, we report the inhibition of Aβ42 aggregation by p-terphenyl derivatives 14 isolated from Boletopsis leucomelas and the hydrolysis derivative 5 and acetyl derivative 6 of compound 3. p-Terphenyl derivatives exhibited aggregation-inhibiting activity in a dose-dependent manner. All of the p-terphenyl derivatives used in this study demonstrated activity, suggesting that daily consumption of foods containing p-terphenyl derivatives may be effective for the prevention and treatment of AD.