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Paper | Regular issue | Vol 104, No. 5, 2022, pp.934-944
Published online, 21st February, 2022
DOI: 10.3987/COM-22-14636
L-Cysteine Catalyzed One-Pot Synthesis of Bicyclic δ-Lactones under Ball-Milling Conditions

Ling Jiang, Qingqing Lu, Qianqian Tang, Yue Cheng, and Xiaohe Chu*

*Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310014, PR China


A series of bicyclic δ-lactones 4a-4t were synthesized in moderate to good yields via a simple one-pot reaction. The facile method depended on one-pot three-component reaction of aromatic aldehyde, Meldrum's acid and β-diketone in the presence of L-cysteine as a catalyst under ball-milling conditions. The reactions were completed in mere 30 min in 50-87% yields. The synthesized compounds were characterized by 1H NMR, 13C NMR and ESI-MS. Environmental acceptability, wide substrate scope, low cost and operational simplicity are the key features of this method.