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Short Paper | Regular issue | Vol 104, No. 5, 2022, pp.952-960
Published online, 2nd February, 2022
DOI: 10.3987/COM-21-14616
Iodine-Promoted Cyclization of Alkylidene Barbiturates in Water: Facile Synthesis of Dihydrofuryl Spirobarbiturates

Zeng-Yang He, Hui Xu,* Wen-Bin Wang, Hua-Jun Xu, and Peng Zou*

*School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, China


An efficient and environmentally benign method via iodine-promoted bimolecular annulation of alkylidene barbiturates in water has been developed, affording a variety of significant spirobarbiturate derivatives in good to excellent yields. All products were directly obtained by filtration and following recrystallization. The present protocol exhibits its advantages in terms of simple operation, high efficiency, good functional group tolerance and feasibility for large-scale synthesis.