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Short Paper | Regular issue | Vol 104, No. 5, 2022, pp.945-951
Published online, 28th January, 2022
DOI: 10.3987/COM-21-14615
A New Monoterpenoid Indole Alkaloid from Uncaria rhynchophylla

Guiyang Wang, Xiao Yu, Linlin Zhu, Yan Liang, Mengnan Zhou, Bin Liu,* and Wei Zhang*

*School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, People’s Republic of China

Abstract

A new alkaloid, uncanidine A (1) and 14 known alkaloids (2-15) were isolated from the hook-bearing branches of Uncaria rhynchophylla. Their structures were elucidated by spectroscopic analyses, including 1D-, 2D-NMR, HR-ESI-MS, ECD, as well as comparison with the data reported in the literature. Noteworthily, uncanidine A (1) was a novel Uncaria alkaloid which possessed a 6/5/6/6/6/5 hexacyclic ring system. In addition, uncanidine A (1) was found to inhibit the generation of NO from RAW 264.7 cells stimulated by LPS.