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Paper | Regular issue | Vol 104, No. 5, 2022, pp.917-924
Published online, 4th February, 2022
DOI: 10.3987/COM-21-14604
Characterization and Antitumor Activity of Furazano[3,4-g]pteridine-2,4(1H,3H)-dione

Yoshimasa Makita,* Shin-ichi Kawaguchi, and Shin-ichi Fujiwara

*Department of Chemistry, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka, Japan, Japan


Alloxazine derivatives exhibit a wide variety of properties imparted by their tautomerization to isoalloxazine and the presence of similar H-bonding to uracil. Herein, we characterized the structure and properties of furazano[3,4-g]pteridine-2,4(1H,3H)-dione (1) by X-ray crystal structure analysis and evaluated its antitumor activity. The IC50 value of 1 was 172 μM, as determined using HeLa cells.