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Paper | Regular issue | Vol 104, No. 3, 2022, pp.470-481
Published online, 2nd December, 2021
DOI: 10.3987/COM-21-14580
An Unprecedented Synthesis of 8b-Hydroxy-3a-(1H-pyrrol-2-yl)/(1H-indol-3-yl)-3a,8b-dihydroindeno[1,2-b]pyrrol-4(1H)-one Derivatives from Pyrrole/Indole with Ninhydrin and β‑Enaminocarbonyls

Mozhgan Masoudi*

*Department of chemistry, Rafsanjan Branch, Islamic Azad University, Rafsanjan, Iran


Heterocyclic systems containing (1H-pyrrol-2-yl) or (1H-indol-3-yl)-dihydroindenopyrrole moieties were synthesized using heterocyclization of pyrrole or indole with ninhydrin and β‑enaminocarbonyls in water under reflux conditions. An efficient, facile, and environmentally friendly protocol was found for the production of new heterocyclic compounds. This reaction was used to gain access to a wide range of pyrrole/indole derivatives. Plate chromatography was utilized to isolate the products whose structures were established from their spectroscopic data.