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Communication | Regular issue | Vol 102, No. 12, 2021, pp.2313-2318
Published online, 6th October, 2021
DOI: 10.3987/COM-21-14545
Synthetic Study of the C’D’E’ Ring System of Maitotoxin via Furan Based Strategy

Yuta Watanabe, Kohei Torikai, Yoko Yasuno, and Tohru Oishi*

*Department of Chemistry, Faculty and Graduate School of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

Abstract

Synthetic study of the C’D’E’ ring system of maitotoxin was examined via Suzuki–Miyaura coupling of an exo-iodoolefin and a furanylborane derivative, followed by Sharpless asymmetric dihydroxylation, Achmatowicz reaction, borylation/oxidation, and reductive etherification.