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■ Semi-Synthetic Chasmanthinine Analogues with Antifeedant Effects against Spodoptera exigua

Ziyu Song, Ke Xu, Jing Li, Yayun Xie, Xiang Li, Shuai Huang, Feng Gao, Lin Chen, and Xianli Zhou*

*School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, P. R. China

Abstract

The synthesis and structure modification of active natural lead compounds is an important approach for the discovery of novel green pesticides. Nineteen derivatives of chasmanthinine, a natural C19-diterpenoid alkaloids, were prepared, and their structures were unambiguously determined by 1H NMR, 13C NMR, and HR-ESI-MS. Moreover, the antifeedant activities of title compounds were evaluated against larvae of Spodoptera exigua (Hübner). The results illustrated that compounds p with a thienyl group at the C-14 position (EC50 = 0.10 mg/cm2) showed the strongest antifeedant activities among all tested compounds. This present study is the first report on the antifeedant effects of synthetic chasmanthinine analogs aganist S. exigua (Hübner) larvae.