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Short Paper | Regular issue | Prepress
Published online, 2nd September, 2021
DOI: 10.3987/COM-21-14529
Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazole by the Reaction of 2-Amino-4,5-dihydro-3-furancarbonitrile and o-Substituted Anilines in the Catalysis of Trimetylamine Hydrochloride

Fumi Okabe-Nakahara,* Hayate Nagabuchi, Eiichi Masumoto, and Hiroshi Maruoka

*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

Abstract

Efficient synthesis of benzimidazoles, benzoxazoles and benzothiazole from the reaction of 2-amino-4,5-dihydro-3-furancarbonitrile with o-substituted anilines in the catalysis of trimethylamine hydrochloride was achieved. The structures of the obtained products were established by spectroscopic data.