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Short Paper | Regular issue | Vol 102, No. 10, 2021, pp.2007-2018
Published online, 29th July, 2021
DOI: 10.3987/COM-21-14513
Microwave-Assisted Synthesis of 2-Aminothiophene Derivatives via Improved Gewald Reactions

Bankang Ruan, Zhiyan Zhang, Lei Huang, Chao Xu, and Luolan Li*

*Shizhen College of Guizhou University of Traditional Chinese Medicine, Shizhen College, Guiyang, China


In this paper, a new and efficient method was developed to prepare 2-aminothiophene derivatives through improved Gewald reaction. Thirty-one final products were synthesized under microwave radiation for 30 min with 57%-95% isolated yield. All the products were could be used as building blocks in drug discovery.