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Short Paper | Regular issue | Vol 102, No. 9, 2021, pp.1810-1816
Published online, 6th July, 2021
DOI: 10.3987/COM-21-14505
Three New Anti-Rotavirus Chromeno[3,2-c]pyridines from the Whole Plant of Thalictrum scabrifolium

Qiu-Fen Hu, Fan Wu, Tao Zhou, Min Zhou, Ya-Ning Zhu, Bing-Biao Cai, Ming-Xin Liu, Man-Fei Li, Guang-Yu Yang,* and Yin-Ke Li*

*Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, Kunming 60500, P. R. China


Three new chromeno[3,2-c]pyridines (1-3) were isolated from the whole plants of Thalictrum scabrifolium. Their structures were elucidated by spectroscopic methods, including extensive 1H, 13C, and 2D-NMR techniques. Compounds 1-3 were also tested for their anti-rotavirus activity, and they exhibited potent anti-rotavirus activity with therapeutic index (TI) valves of 23.7, 18.3, and 19.2 respectively.