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Short Paper | Regular issue | Vol 102, No. 9, 2021, pp.1791-1796
Published online, 15th June, 2021
DOI: 10.3987/COM-21-14493
Concise Synthesis of Eutigoside C

Shiqiang Yan, Yueyue Zhu, Lisha Wu, Liqun Chi,* and Wei Zhang*

*School of Pharmacy, Fudan University, Shanghai, 201203, China


Eutigoside C, a new glucoside with a variety of biological activities, was synthesized via regioselective Me2SnCl2-catalyzed O-6 acylation and mild oxidation strategy. Through this route, eutigoside C was obtained from inexpensive starting materials in a linear 5-step sequence with an overall yield of 35.2%.