HETEROCYCLES

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■ Synthesis and Biological Activity Evaluation of Imidazole Heterocyclic Sulfonylurea Compounds

Wei Li, Jinze Pei, Yang Chen, and Guangshan Xuan*

*College of Chemical Engineering, Qingdao University of Science & Technology, 53 Zhengzhou Road, Shibei District, Qingdao, Shandong Province, China

Abstract

Sulfonylurea herbicides are the most widely used herbicides in the world. They have the advantages of high efficiency, good selectivity, and no toxicity to human and animals. In this study, sulfonylureas containing imidazole heterocycles were synthesized on the basis of computer simulation of molecular docking, and the biological activity was evaluated. It shows that the compound has a good inhibitory effect on the ALS and a certain inhibitory effect on the phytopathogenic fungi of Curvularia lunata and Curvularia mebaldsii. Its inhibitory rate at concentration of 50 mg/L is similar to that of the carbendazim. This research provides the basis for further optimization of the structure of imidazolium heterocyclic sulfonylurea and the synthesis of its derivatives.