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■ Novel Synthesis and Properties of Optically Pure N-Trifluoroacetylphenylglycine Hydroxysuccinimide Ester

Zeping Wang, Shoko Ishikawa, Fumina Ohashi, Reo Sagisaka, Yuta Murai, Zetryana Puteri Tachrim, Takeyuki Suzuki, and Makoto Hashimoto*

*Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita-ku, Sapporo, Hokkaido, Japan

Abstract

Phenylglycine is non-proteinogenic α-amino acid, and its partial structure is found in some biologically active compounds. C-Terminal modification of N-acyl-protected phenylglycine sometimes causes racemization due to the fact that the phenyl ring is directly connected to the α-position of the α-amino acid skeleton. In this report, synthesis and the property of N-trifluoroacetylphenylglycine hydroxysuccinimide ester was archived.