Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 105, No. 1, 2022, pp.406-416
Published online, 31st March, 2022
DOI: 10.3987/COM-22-S(R)11
Novel Synthesis and Properties of Optically Pure N-Trifluoroacetylphenylglycine Hydroxysuccinimide Ester

Zeping Wang, Shoko Ishikawa, Fumina Ohashi, Reo Sagisaka, Yuta Murai, Zetryana Puteri Tachrim, Takeyuki Suzuki, and Makoto Hashimoto*

*Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita-ku, Sapporo, Hokkaido, Japan


Phenylglycine is non-proteinogenic α-amino acid, and its partial structure is found in some biologically active compounds. C-Terminal modification of N-acyl-protected phenylglycine sometimes causes racemization due to the fact that the phenyl ring is directly connected to the α-position of the α-amino acid skeleton. In this report, synthesis and the property of N-trifluoroacetylphenylglycine hydroxysuccinimide ester was archived.