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■ Anti-Tobacco Mosaic Virus Isoindolin-1-ones from the Stems of Nicotiana tabacum

Jian-Duo Zhang, Xin Liu, Li Xu, Jia-Rui Jiang, Le-Le Deng, Wen-Wu Yang, Xue-Mei Li, Guang-Yu Yang, Tao Zhou,* and Feng-Xian Yang*

*Technology Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming, Yunnan 650231, China

Abstract

Three new (1-3) and three known (4-6) isoindolin-1-ones were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-3 were tested for their anti-tobacco mosaic virus (anti-TMV) activitiy. The results showed that compounds 1-3 showed high anti-TMV activity with inhibition rates of 42.6, 46.7 and 38.5% at the concentration of 20 μM, respectively. These rates are higher than that of ningnanmycin, a positive control.