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Paper | Regular issue | Vol 102, No. 4, 2021, pp.675-685
Published online, 18th February, 2021
DOI: 10.3987/COM-20-14398
Synthesis of 4-Hydroxyaurones and Their Herbicidal Activities

Mei Xia, Min Zhang,* Jianfen Ding, Jiankai Hong, Yuting Shen, and Liuqing Yang*

*School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China


A series of 4-hydroxyaurone derivatives 4a-4v were synthesized and characterized by 1H NMR, 13C NMR, and elemental analysis. Their herbicidal activities against four species of plants were evaluated in a greenhouse by both pre- and post-emergence treatments at a dosage of 750 g a.i. ha-1. The bioassay revealed that 4-hydroxyaurones exhibited moderate to good herbicidal activities against dicotyledons plants for post-emergence treatment. For instance, (Z)-4-hydroxy-2-(4-nitrobenzylidene)benzofuran-3(2H)-one (4m), demonstrated 74.5% inhibitory activity against Amaranthus retroflexus L., higher than that of the positive control herbicide acetochlor. Thus, compound 4m may serve as a new possible leading compound for the discovery of post-emergence herbicide.