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Short Paper | Regular issue | Vol 102, No. 1, 2021, pp.114-121
Published online, 24th November, 2020
DOI: 10.3987/COM-20-14365
Liquid-Assisted Mechanosynthesis of trans-2,3-Dihydropyrroles from Chalcones and Enaminones

Ming-Yue Weng, Hui Xu,* Hong Chen, and Ze Zhang*

*Anhui Province Key Laboratory of Functional Coordinated Complexes for Materials Chemistry and Application, and School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, P. R. China


An efficient synthesis of a variety of trans-2,3-dihydropyrroles via iodine-promoted cyclization between chalcones and enaminones has been demonstrated under liquid-assisted grinding conditions. The present protocol provides a practical, fast and green alternative to traditional solvent-based methods due to its notable advantages such as significantly higher yield, much shorter reaction time, good functional group tolerance and mild reaction conditions.