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■ A Simple Route for Synthesis and Evaluation of Antioxidant Activity of (Guaiazulen-1-yl)furans

Si-Tong Guo, Jiao Xu, Xiao-Liang Zhang, Xin-Shuang Xiong, Lu Zhang, Dao-Lin Wang,* and Shu-Quan Zhang*

*College of Chemistry and Material Science, Bohai University, Jinzhou, China

Abstract

An effective protocol for the synthesis of guaiazulene substituted furan derivatives via three-component reactions of guaiazulene, α-ketoaldehyde, and 1,3-dicarbonyl compound under mild conditions in good yield is reported. All of these compounds were evaluated for their antioxidant properties in vitro against lipid peroxidation and several compounds were found to have good activities.