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Short Paper | Special issue | Vol 103, No. 1, 2021, pp.544-553
Published online, 3rd December, 2020
DOI: 10.3987/COM-20-S(K)40
Concise Synthesis of an Amide-Functionalized [7]Helicene-like Molecule via Intramolecular Amidation

Yongning Xing, Masanori Nikaido, Takuya Murai, Shohei Hamada, Yusuke Kobayashi, Takahiro Sasamori, Takeo Kawabata, and Takumi Furuta*

*Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan


A concise synthesis of an amide-functionalized [7]helicene-like molecule was achieved via the intramolecular amidation of an in-situ-generated biaryl δ-amino acid derivative. An X-ray analysis of racemic mixture of this helicene-like molecule revealed a helically twisted π-system and that the (M)- and (P)-isomers associate pairwise via hydrogen-bonding interactions, which results in a one-dimensional columnar packing in the crystal structure.