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Paper | Regular issue | Vol 102, No. 4, 2021, pp.647-658
Published online, 4th February, 2021
DOI: 10.3987/COM-20-14384
Microwave-Assisted and Solvent-Free Synthesis of Quinoline Derivatives and Their Fluorescence Properties

Xiaobin Zhang, Xiumei Ma, Yun Ai, Yuanyuan Ren, Xiao Bai, Huan Chen, Ying Zhou, Wenyu Li, Cuiling Wang,* and Yifeng Liu

*College of Life Sciences, Northwest University, No. 229, Taibai North Road, Xi'an, Shaanxi 710069, China


A protocol for the microwave-assisted Friedländer synthesis of quinoline derivatives under solvent-free conditions has been developed. According to this modified method, quinoline derivatives were synthesized by condensation of 2-aminobenzophenone with the corresponding carbonyl compounds in the presence of phosphomolybdic acid for 8 min in a 320 W microwave with yields ranging from 61% to 90%. The fluorescence properties of the synthesized compounds were studied, and all compounds showed good fluorescence properties. The substituted groups and the concentrations of quinolines and solvents had significant effects on the compounds’ fluorescence properties. This method provides a convenient way to obtain quinolines, and is beneficial to the application of these compounds.