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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Paper | Regular issue | Vol 100, No. 12, 2020, pp.2033-2049
Published online, 7th October, 2020■ Synthesis of Pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-ones and Related New Heterocycles
Published online, 7th October, 2020
DOI: 10.3987/COM-20-14337
■ Synthesis of Pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-ones and Related New Heterocycles
Tamás Zelenyák, Imre Fejes, Jérôme-Benoît Starck, and Miklós Nyerges*
*Servier Research Institute of Medicinal Chemistry, 7 Záhony utca., 1031, Budapest, Hungary
Abstract
During our synthetic development work focused on new Bcl-2 inhibitor molecules an unexpected and interesting by-product was formed. Using this obsevation we have explored the synthesis of the hitherto unknown pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-one heterocyclic core. The study of the scope and limitations of this cyclisation resulted in other three new types of three membered heterocyclic ring systems.
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