Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 100, No. 12, 2020, pp.2033-2049
Published online, 7th October, 2020
DOI: 10.3987/COM-20-14337
Synthesis of Pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-ones and Related New Heterocycles

Tamás Zelenyák, Imre Fejes, Jérôme-Benoît Starck, and Miklós Nyerges*

*Servier Research Institute of Medicinal Chemistry, 7 Záhony utca., 1031, Budapest, Hungary


During our synthetic development work focused on new Bcl-2 inhibitor molecules an unexpected and interesting by-product was formed. Using this obsevation we have explored the synthesis of the hitherto unknown pyrrolo[2,3]pyrido[2,4-d]pyrimidin-6-one heterocyclic core. The study of the scope and limitations of this cyclisation resulted in other three new types of three membered heterocyclic ring systems.