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Short Paper | Regular issue | Vol 100, No. 11, 2020, pp.1902-1913
Published online, 19th August, 2020
DOI: 10.3987/COM-20-14325
Synthesis of Some Novel Antimicrobial and Antioxidant Agents of Functionalized Pyrazolo[4',3':5,6]pyrano[3,2-d]- [1,2]azaphospholes and Pyrazolo[4',3':5,6]pyrano[2,3-d][1,3,2]diazaphosphinines

Noha M. Hassanin,* Tarik E. Ali, Hafez M. El-Shaaer, Somaia M. Abdel-Kariem, Somaya M. El-Edfawy, and Wafaa R. Abdel-Monem

*Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11757, Cairo, Egypt

Abstract

We have demonstrated facile synthetic approach for some novel functionalized pyrazolo[4',3':5,6]pyrano[3,2-d]-[1,2]azaphospholes and pyrazolo[4',3':5,6]pyrano[2,3-d][1,3,2]diazaphosphinines via treatment of 6-amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile with some phosphorus halides. The structure of the products was characterized by elemental analysis and spectral tools. The antimicrobial and antioxidant activities of the products were also evaluated.