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Short Paper | Regular issue | Vol 100, No. 10, 2020, pp.1645-1656
Published online, 20th August, 2020
DOI: 10.3987/COM-20-14306
Synthesis and Reactions of 3,8-Diphenyl-5-(4-methoxyphenyl)pyrrolo[1,2-c][1,3]thiazolo[3,2-a]pyrimidine-6-carbohydrazide

Kamelia M. El-mahdy and Azza M. El-kazak*

*Department of Chemistry, Faculty of Education, Ain Shams University, Roxy 11757, Cairo, Egypt

Abstract

The reaction of 2-mercaptopyrimidine 1 with phenacyl bromide gave pyrrolothiazolopyrimidine 2, which underwent hydrazinolysis to produce the novel pyrrolo[1,2-c][1,3]thiazolo[3,2-a]pyrimidine-6-carbohydrazide 3. Compound 3 used as a key intermediate for the synthesis of poly fused and isolated systems bearing pyrrolo[1,2-c][1,3]thiazolo[3,2-a]pyrimidine moiety via its reactions with some heterocyclization reagents. Structures of the newly synthesized compounds were established by elemental analysis and spectral data (IR, 1H NMR, Mass spectra and 13C NMR). The prepared compounds would be expected to have biological activities.