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Short Paper | Regular issue | Vol 100, No. 10, 2020, pp.1633-1644
Published online, 20th August, 2020
DOI: 10.3987/COM-20-14305
Identification and Characterization of Chlorine-Containing Briaranes from a Cultured Octocoral Briareum excavatum (Briareidae)

Yi-Lin Zhang, Liang-Mou Kuo, Lo-Yun Chen, Gene-Hsiang Lee, Bo-Rong Peng, You-Ying Chen, Yu-Hsin Chen, Tsong-Long Hwang,* Jyh-Horng Sheu,* and Ping-Jyun Sung*

*Department of Planning and Research, National Museum of Marine Biology and Aquarium, 2 Houwan Road, Checheng, Pingtung, Taiwan 944, Taiwan

Abstract

Six chlorine-containing briaranes, including two new compounds, briarenols M (1) and N (2), as well as four known metabolites solenolide E (3), briarenolide R (4), excavatolide A (5), and briaexcavatolide F (6), have been isolated from a cultured octocoral identified as Briareum excavatum. The structures of 1 and 2 were established by spectroscopic methods and the absolute configurations of 5 and 6 were confirmed by single-crystal X-ray diffraction analysis. These compounds were subjected into the inhibitory effects on fMLF/CB stimulated superoxide anion generation and elastase release in human neutrophils.