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Paper | Regular issue | Vol 100, No. 10, 2020, pp.1579-1598
Published online, 20th August, 2020
DOI: 10.3987/COM-20-14300
An Efficient Synthesis of Some New Coumarin Hybrids Endowed with Expected Biological Activity

Mohamed A. Raslan,* Noura Sh. Hagaggi, Kamal M. Dawood, Hany A. Abdel Atty, and Ayman Nafady

*Department of Chemistry, Faculty of Science, Aswan University, Aswan 81528, Egypt


Reactions of 5-bromo-2-hydroxybenzaldehyde with cyanoacetic acid hydrazide derivatives in refluxing ethanol afforded some new chromene-based polyfunctionally substituted heteroaromatics. The antimicrobial activity of some of the obtained products was evaluated. The structures of the newly synthesized compounds were elucidated based on their elemental analyses and spectral data.