Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 103, No. 1, 2021, pp.348-364
Published online, 7th August, 2020
DOI: 10.3987/COM-20-S(K)18
Copper-Mediated Trifluoromethylation of Borylporphyrins Using an in situ-Generated CF3 Radical from NaSO2CF3 and tert-Butyl Hydroperoxide

Satoshi Hayashi,* Daisuke Yamazaki, and Toshikatsu Takanami*

*Department of Life and Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

We developed a method for the copper-mediated reaction of borylated Ni(II) porphyrins using NaSO2CF3 (Langlois’ reagent) and tert-butyl hydroperoxide (TBHP) to prepare trifluoromethylated Ni(II) porphyrins.Porphyrin trifluoromethylation can be carried out under mild conditions and exhibits both excellent substrate generality and functional group compatibility.