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Paper | Regular issue | Vol 100, No. 7, 2020, pp.1009-1018
Published online, 12th May, 2020
DOI: 10.3987/COM-20-14257
HBTU-Catalyzed Simple and Mild Protocol for the Synthesis of Quinoxaline Derivatives

Bhushan B. Popatkar* and Gangadhar A. Meshram

*Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (E), Mumbai, India


HBTU-catalyzed, simple, mild, and effective protocol for the synthesis of quinoxalines has been established. The reaction between 1,2-diamines, benzil, and catalytic amount of HBTU in ethanol resulted into quinoxalines. Various aliphatic, aromatic and heterocyclic 1,2-diamines reacted smoothly with benzil to obtained the title compounds in moderate to high overall yield. Use of environmentally benign solvent, high yield of the product, comparably less reaction time and mild reaction condition are advantages of this method.