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Short Paper | Regular issue | Vol 100, No. 5, 2020, pp.809-822
Published online, 15th April, 2020
DOI: 10.3987/COM-20-14249
Efficient Synthesis of Some New 1,3,4-Thiadiazole and Thiazole Derivatives via Thiosemicarbazone Derivatives

Mohamed Abdelmonem Raslan*

*Department of Chemistry, Faculty of Science, Aswan University, Aswan 81528, Egypt


We reported here reactions of hydrazinecarbodithioate and hydrazinecarbothioamide derivatives with hydrazonoyl chloride derivatives to afford 1,3,4-thiadiazole and thiazole derivatives, respectively. Also, reactions of hydrazinecarbothioamide derivatives with α-halo esters derivatives, diethyl acetylenedicarboxylate and chloroacetonitrile afforded thiazole derivatives. The structures of the newly synthesized compounds were established based on its elemental analyses and spectral data.