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Short Paper | Special issue | Vol 103, No. 1, 2021, pp.459-464
Published online, 13th May, 2020
DOI: 10.3987/COM-20-S(K)5
Conjugate Addition Reaction of Indole to Protected 2-Amino-1-nitroethenes Mediated by Silica Gel

Kenichi Murai,* Shuji Miyazaki, and Hiromichi Fujioka*

*Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka 560-0871, Japan

Abstract

We have developed a silica-gel-mediated route for the conjugate addition of indole to protected 2-amino-1-nitroethenes for the synthesis of 1-indolyl-1,2-ethanediamines. This is the first demonstration of indole as the nucleophile for addition to protected 2-amino-1-nitroethenes.