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Short Paper | Regular issue | Vol 100, No. 3, 2020, pp.451-462
Published online, 19th February, 2020
DOI: 10.3987/COM-20-14209
A Facile Synthesis and Antibacterial Activity of Novel Quinoxaline-Benzofuran Hybrids

Yang Li, Bingyue Tang, Shiyu Dong, Hongwei Qin, Wentao Gao,* and Yu Chen*

*Institute of Superfine Chemicals, School of Chemistry and Chemical Engineering, Bohai University, 19 Keji Road, Jinzhou 121000, China


In the present work, a simple and facile synthesis of a series of new type of quinoxaline-benzofuran hybrids, i.e., 3-(benzofuran-2-yl)quinoxaline- 2-carboxylic acids has been achieved using the newly-synthesized ethyl 3-bromomethylquinoxaline-2-carboxylate as substrate through ultrasound-assisted one-pot sequential Rap-Stoermer type reaction with various salicylaldehydes followed by ester hydrolysis. A preliminary screening for their antibacterial activities against five bacterial strains revealed that compounds with tert-butyl and halo (Cl and Br) substituents exhibited promising inhibitory activity against B. subtilis with the MIC values of 15.625 and 7.8125 μg/mL, respectively, being equipotent or even better than the reference Ciprofoxacin.