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Short Paper | Regular issue | Vol 100, No. 6, 2020, pp.947-954
Published online, 28th April, 2020
DOI: 10.3987/COM-20-14210
Facile Synthesis of 2-Aryl(guaiazulen-1-yl)methylkojic Acid Derivatives via Benzylation

Xin-Shuang Xiong, Dao-Lin Wang,* Si-Tong Guo, and Xiao-Liang Zhang

*College of Chemistry and Chemical Engineering, Bohai University, 19, Keji Rd., New Songshan District, Jinzhou City, Liaoning Province 121001, China


A facile and efficient one-pot procedure for the preparation of 2-aryl(guaiazulen-1-yl)methylkojic acid derivatives by a catalyst-free, benzylation of guaiazulene with kojic acid-substituted benzylic alcohols under mild conditions in good yield is reported.