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Short Paper | Special issue | Vol 103, No. 1, 2021, pp.476-483
Published online, 13th May, 2020
DOI: 10.3987/COM-20-S(K)11
Synthesis of Pyrrolo[1,2-c]pyrimidines

Easha Narayan, Liangfeng Fu, and Gordon W. Gribble*

*6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, U.S.A.

Abstract

The synthesis of several new pyrrolo[1,2-c]pyrimidines from the base-induced condensation of pyrrolo-2-carbaldehydes with either TosMIC (toluenesulfonylmethyl isocyanide) or ethyl isocyanoacetate is described, along with the preparation of novel bis(pyrrolo[1,2-c]pyrimidines).